Inhibition of basophil histamine release by methotrexate

  title={Inhibition of basophil histamine release by methotrexate},
  author={H. Nolte and P. Stahl Skov},
  journal={Agents and Actions},
  • H. Nolte, P. Stahl Skov
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
  • Basophil leukocytes in whole blood from 4 healthy donors, 4 atopic patients and 10 female patients operated for breast-cancer were preincubated from 1 to 20 hrs alone or in the presence of methotrexate (MTX) or MTX and folinic acid. After preincubation, the basophil leukocytes were challenged with anti-IgE, allergens or the calcium ionophore A23187 in the presence of 25 ng/ml TPA (12-o-tetradecanoyl-phorbol-13-acetate).A 9-hr preincubation with MTX produced significant inhibition of histamine… CONTINUE READING

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