Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo.

@article{Wilkinson2002InhibitionOB,
  title={Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo.},
  author={Ian B. Wilkinson and Helen MacCallum and John R. Cockcroft and David J. Webb},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={53 2},
  pages={189-92}
}
AIMS To investigate the role of basal nitric oxide (NO) production in regulating large artery stiffness in vivo. METHODS Incremental doses of the NO synthase inhibitor L-N(G)-monomethyl arginine (LNMMA: 0.1, 0.3, 1.0 and 3.0 mg kg-1 min-1) or placebo were infused in eight healthy men. Arterial stiffness was assessed noninvasively by pulse wave analysis. RESULTS Compared with placebo, infusion of LNMMA led to a dose-dependent increase in mean arterial pressure, peripheral vascular resistance… CONTINUE READING