Inhibition of bFGF/EGF-dependent endothelial cell proliferation by the hyaluronan-binding protease from human plasma.

@article{Etscheid2004InhibitionOB,
  title={Inhibition of bFGF/EGF-dependent endothelial cell proliferation by the hyaluronan-binding protease from human plasma.},
  author={Michael Etscheid and Nicole Beer and Julia Anne Kress and R. Seitz and Johannes Dodt},
  journal={European journal of cell biology},
  year={2004},
  volume={82 12},
  pages={597-604}
}
Recently we identified a plasma serine protease with a high affinity to glycosaminoglycans like heparin or hyaluronic acid, termed hyaluronan-binding protease (HABP). Since glycosaminoglycans are found on cell surfaces and in the extracellular matrix a physiological role of this plasma protease in a pericellular environment was postulated. Here we studied the influence of HABP on the regulation of endothelial cell growth. We found that HABP efficiently prevented the basic fibroblast growth… CONTINUE READING
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