Inhibition of axon growth by oligodendrocyte precursor cells.

  title={Inhibition of axon growth by oligodendrocyte precursor cells.},
  author={Z. J. Chen and Yvonne M Ughrin and Joel M. Levine},
  journal={Molecular and cellular neurosciences},
  volume={20 1},
The glial scar that forms at the site of injury is thought to be a biochemical and physical barrier to successful regeneration, although the molecules responsible for this barrier function are not well understood. Glia scars contain large numbers of oligodendrocyte precursor cells (OPCs) and these cells can produce several different growth-inhibitory chondroitin sulfate proteoglycans (CSPGs), including NG2, neurocan, and phosphacan. Here, we used membrane-based assays to show that the surface… CONTINUE READING


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