Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression.

@article{Mo2014InhibitionOA,
  title={Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression.},
  author={Ning Mo and Yong-Kui Lu and Wei-min Xie and Yan Liu and W Zhou and Hong-Xue Wang and Li Nong and Yu-Xian Jia and Ai-Hua Tan and Ying Chen and Shan-shan Li and Bao-Hua Luo},
  journal={Oncology reports},
  year={2014},
  volume={32 5},
  pages={1905-12}
}
Radiotherapy has long been considered as the mainstay of treatment for nasopharyngeal carcinoma (NPC). However, locoregional recurrence or distant metastasis may occur in some patients due to the radiation resistance of cancer cells. Autophagy plays a vital role in protecting cells against radiation. However, the mechanism of autophagy in radiation therapy remains obscure. In the present study, we demonstrated that suppression of autophagy related 5 (Atg5) aggravated ionizing radiation (IR… CONTINUE READING
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