Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.

@article{Botta2012InhibitionOA,
  title={Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.},
  author={Ginevra Botta and Carmela Passaro and Silvana Libertini and Antonella Abagnale and Sara Barbato and Angela Serena Maione and Gunnel Halld{\'e}n and Francesco B{\'e}guinot and Pietro Formisano and Giuseppe Portella},
  journal={Human gene therapy},
  year={2012},
  volume={23 6},
  pages={623-34}
}
Oncolytic viruses represent a novel therapeutic approach for aggressive tumors, such as glioblastoma multiforme, which are resistant to available treatments. Autophagy has been observed in cells infected with oncolytic viruses; however, its role in cell death/survival is unclear. To elucidate the potential therapeutic use of autophagy modulators in association with viral therapy, we analyzed autophagy induction in human glioma cell lines U373MG and U87MG infected with the oncolytic adenovirus… CONTINUE READING
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