Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells.

@article{Xu2012InhibitionOA,
  title={Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells.},
  author={Ye Xu and Huimei Yu and Hanjiao Qin and Jinsong Kang and Chunyan Yu and Jiateng Zhong and Jing Su and Hongyan Li and Lian-Kun Sun},
  journal={Cancer letters},
  year={2012},
  volume={314 2},
  pages={232-43}
}
The function of autophagy in cisplatin-treated cancer cells is not fully understood. Cisplatin treatment induced degradation of ubiquitinated proteins by autophagy, which reduced apoptosis induced by endoplasmic reticulum (ER) stress and downregulated the mitochondrial pathway of apoptosis. Inhibition of autophagy using 3-methyladenine (3-MA) or chloroquine (CQ) increased the levels of intracellular misfolded proteins, which enhanced cellular apoptosis. We found that tunicamycin, an ER stress… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…