Inhibition of autophagy and enhancement of endoplasmic reticulum stress increase sensitivity of osteosarcoma Saos‐2 cells to cannabinoid receptor agonist WIN55,212‐2

@article{Zhang2016InhibitionOA,
  title={Inhibition of autophagy and enhancement of endoplasmic reticulum stress increase sensitivity of osteosarcoma Saos‐2 cells to cannabinoid receptor agonist WIN55,212‐2},
  author={G. Zhang and H. Bi and Ji Gao and X. Lu and Yanping Zheng},
  journal={Cell Biochemistry and Function},
  year={2016},
  volume={34},
  pages={351 - 358}
}
  • G. Zhang, H. Bi, +2 authors Yanping Zheng
  • Published 2016
  • Biology, Medicine
  • Cell Biochemistry and Function
  • WIN55,212‐2, a cannabinoid receptor agonist, can activate cannabinoid receptors, which has proven anti‐tumour effects in several tumour types. Studies showed that WIN can inhibit tumour cell proliferation and induce apoptosis in diverse cancers. However, the role and mechanism of WIN in osteosarcoma are still unclear. In this study, we examined the effect of WIN55,212‐2 on osteosarcoma cell line Saos‐2 in terms of cell viability and apoptosis. Meanwhile, we further explored the role of… CONTINUE READING
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