Inhibition of aryl sulfotransferase by carboxylic acids.

  title={Inhibition of aryl sulfotransferase by carboxylic acids.},
  author={Shrikanth Rao and Michael W. Duffel},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={19 2},
Aryl sulfotransferase (AST) IV catalyzes the 3'-phosphoadenosine-5'-phosphosulfate-dependent formation of sulfuric acid esters of a wide range of phenols, benzylic alcohols, hydroxamic acids, catecholamines, tyrosine carboxylesters, and peptides with N-terminal tyrosines. The objective of this investigation was to determine whether aryl carboxylic acids could act either as substrates or inhibitors for AST IV. These studies were conducted with AST IV that was purified to homogeneity from male… CONTINUE READING