Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes.

@article{Uchi2017InhibitionOA,
  title={Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes.},
  author={Hiroshi Uchi and Mao Yasumatsu and Saori Morino-Koga and Chikage Mitoma and Masutaka Furue},
  journal={Journal of dermatological science},
  year={2017},
  volume={85 1},
  pages={
          36-43
        }
}
BACKGROUND Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS Keratinocytes were used in this study because the skin is one of the organs most… CONTINUE READING
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