Inhibition of arthritis by systemic administration of endostatin in passive murine collagen induced arthritis.

Abstract

OBJECTIVE To investigate the arthritis inhibiting effect of endostatin, known to have potent antiangiogenic activity, systemically given to animal models of rheumatoid arthritis (RA). METHODS Four kinds of monoclonal anti-type II collagen antibody followed by lipopolysaccharide (LPS) three days later were given to 6 week old, female Balb/c mice to induce… (More)

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