Inhibition of arachidonic acid release as the mechanism by which glucocorticoids inhibit endotoxin-induced diarrhoea.

@article{Doherty1981InhibitionOA,
  title={Inhibition of arachidonic acid release as the mechanism by which glucocorticoids inhibit endotoxin-induced diarrhoea.},
  author={Niall S. Doherty},
  journal={British journal of pharmacology},
  year={1981},
  volume={73 2},
  pages={549-54}
}
1 Dexamethasone blocked endotoxin-induced diarrhoea in mice, but not that induced by arachidonic acid or prostaglandin E2. 2 Indomethacin blocked endotoxin and arachidonic acid-induced diarrhoea, but not that induced by prostaglandin E2. 3 Codeine blocked all three forms of diarrhoea. 4 The above data, when considered in relation to literature reports that endotoxin induces prostaglandin synthesis, suggest that dexamethasone blocks diarrhoea by preventing the release of arachidonic acid, the… CONTINUE READING