Inhibition of apoptosis in human laryngeal cancer cells by E6 and E7 oncoproteins of human papillomavirus 16

  title={Inhibition of apoptosis in human laryngeal cancer cells by E6 and E7 oncoproteins of human papillomavirus 16},
  author={Han Ching Liu and George G. Chen and A. Vlantis and G. Tse and A. Chan and C. V. van Hasselt},
  journal={Journal of Cellular Biochemistry},
  • Han Ching Liu, George G. Chen, +3 authors C. V. van Hasselt
  • Published 2008
  • Biology, Medicine
  • Journal of Cellular Biochemistry
The carcinogenesis of human papillomaviruses type 16 (HPV‐16) is mainly due to its two oncoproteins, E6 and E7. Their carcinogenic features in term of their relationship with Bcl‐2 family are still unclear. We thus aimed to analyze the expression of Bcl‐2 family members, Bcl‐2, Bax, and Bak in laryngeal cancer cells transfected with the E6 or E7 and to determine the sensitivity of these cells to apoptotic stimuli. We employed two human laryngeal cancer cell lines, UMSCC12 and UMSCC11A in this… Expand
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