Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain.

@article{Revilla1997InhibitionOA,
  title={Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain.},
  author={Yolanda Revilla and Ana C. Cebri{\'a}n and Elena Baixeras and Constantino Mart{\'i}nez and E. Vinuela and Mar{\'i}a L. Salas},
  journal={Virology},
  year={1997},
  volume={228 2},
  pages={400-4}
}
The function of the African swine fever virus (ASFV) bcl-2 homologue, gene A179L, in the regulation of apoptosis was investigated using as a model system the human myeloid leukemia cell line K562 induced to die by apoptosis with inhibitors of macromolecular synthesis, a process that is prevented by overexpression of human bcl-2. It is shown that transfection of K562 cells with the ASFV A179L gene protects these cells from apoptotic cell death induced by a combination of cycloheximide and… CONTINUE READING