Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome.

@article{Slape2012InhibitionOA,
  title={Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome.},
  author={Christopher I Slape and Jesslyn Saw and Jeremy B. M. Jowett and Peter D Aplan and Andreas Strasser and Stephen M Jane and David J Curtis},
  journal={Blood},
  year={2012},
  volume={120 12},
  pages={
          2475-83
        }
}
Programmed cell death or apoptosis is a prominent feature of low-risk myelodysplastic syndromes (MDS), although the underlying mechanism remains controversial. High-risk MDS have less apoptosis associated with increased expression of the prosurvival BCL2-related proteins. To address the mechanism and pathogenic role of apoptosis and BCL2 expression in MDS, we used a mouse model resembling human MDS, in which the fusion protein NUP98-HOXD13 (NHD13) of the chromosomal translocation t(2;11)(q31… CONTINUE READING

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