Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.

Abstract

Ras functions as a molecular switch for several downstream targets and may promote either apoptosis or survival dependent upon the cell system and stimulus. The functional significance of a transfected K-Ras oncogene in influencing apoptosis induced by thymineless stress was examined in a thymidylate synthase (TS)-deficient (TS-) colon carcinoma cell line… (More)

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