Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.

Abstract

Inhibition of VLDL secretion reduces plasma levels of atherogenic apolipoprotein B (apoB) lipoproteins but can also cause hepatic steatosis. Approaches targeting apoB synthesis, which lies upstream of VLDL secretion, have potential to effectively reduce dyslipidemia but can also lead to hepatic accumulation of unsecreted triglycerides (TG). Here, we found… (More)
DOI: 10.1172/JCI86028

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@article{Conlon2016InhibitionOA, title={Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.}, author={Donna M. Conlon and Tiffany Thomas and Tatyana Fedotova and Antonio Hern{\'a}ndez-Ono and Gilbert di Paolo and Robin Barry Chan and Kelly V Ruggles and Sarah Gibeley and Jing Liu and Henry N. Ginsberg}, journal={The Journal of clinical investigation}, year={2016}, volume={126 10}, pages={3852-3867} }