Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo.

@article{Renukaradhya2006InhibitionOA,
  title={Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo.},
  author={Gourapura J. Renukaradhya and Venkataraman Sriram and Wenjun Du and Jacquelyn Gervay-Hague and Luc Van Kaer and Randy R Brutkiewicz},
  journal={International journal of cancer},
  year={2006},
  volume={118 12},
  pages={3045-53}
}
We have investigated the role of the host's CD1d-dependent innate antitumor immune response in a murine T-cell lymphoma model in vivo. We found that C57BL/6 wildtype (WT) mice inoculated with RMA/S cells transfected with murine CD1d1 died at the same rate as mice inoculated with vector-transfected cells. In contrast, natural killer T (NKT) cell-deficient CD1d or Jalpha18 knockout mice inoculated with CD1d-transfected RMA/S cells survived significantly longer than mice inoculated with vector… CONTINUE READING
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