Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.


Histidine-rich protein II (HRPII) is an abundant protein released into the bloodstream by Plasmodium falciparum, the parasite that causes the most severe form of human malaria. Here, we report that HRPII binds tightly and selectively to coagulation-active glycosaminoglycans (dermatan sulfate, heparan sulfate, and heparin) and inhibits antithrombin (AT). In… (More)
DOI: 10.1182/blood-2010-12-326876

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