Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

  title={Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients},
  author={Sebastian Haertter and Hermann Wetzel and Elke Hammes and Christoph Hiemke},
Bidirectional drug interactions between fluvoxamine and classical antidepressants were studied in depressed patients. A column switching technique combined with high performance liquid chromatography (HPLC) enabled automated analyses of plasma for simultaneous determination of fluvoxamine, tricyclic and tetracyclic antidepressants and demethylated and major hydroxylated metabolites in a single HPLC run. The measurements revealed that fluvoxamine inhibited N-demethylation of imipramine… CONTINUE READING


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