Inhibition of antibody synthesis and expression of T-cell membrane markers by serum factors of patients with small cell carcinoma of the lung.

@article{Manke1986InhibitionOA,
  title={Inhibition of antibody synthesis and expression of T-cell membrane markers by serum factors of patients with small cell carcinoma of the lung.},
  author={H. G. Manke and Paul Aulenbacher and S R{\"u}ster and Peter Drings},
  journal={Anticancer research},
  year={1986},
  volume={6 4},
  pages={869-73}
}
Serum of patients with small cell lung cancer as well as serum fractions recovered by column chromatography inhibit the in vitro antibody synthesis in a PWM driven lymphocyte culture system and the capacity of T-lymphocytes to form rosettes with sheep erythrocytes. Utilizing an in vitro antibody synthesis system recomposed of previously separated B-cells and T-helper cells, we could show that the inhibiting high-molecular weight factors (between 40,000 to 60,000 dalton) from the patients' serum… CONTINUE READING