Inhibition of angiotensin-converting enzyme reduces susceptibility of hypertrophied rat myocardium to ventricular fibrillation.

@article{Shimada2002InhibitionOA,
  title={Inhibition of angiotensin-converting enzyme reduces susceptibility of hypertrophied rat myocardium to ventricular fibrillation.},
  author={Yasuyuki Shimada and Suba Gunasegaram and Hiroyuki Yokoyama and Metin Avkiran},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2002},
  volume={66 11},
  pages={1045-53}
}
Left ventricular (LV) hypertrophy increases susceptibility to reperfusion arrhythmias and the angiotensin-converting enzyme inhibitor, ramipril, may reduce that susceptibility via regression of LV hypertrophy. Rats (n=12 per group) were subjected to abdominal aortic constriction (AC) or sham-operation (SH) and from 3 to 6 weeks after surgery, 3 AC groups received ramipril (0.01, 0.1, or 1 mg/kg per day p.o.) while the SH and 1 AC group received vehicle. Six weeks after surgery (ie after 3 weeks… CONTINUE READING
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