Inhibition of angiotensin converting enzyme activity in cultured endothelial cells by hypoxia.

@article{Stalcup1979InhibitionOA,
  title={Inhibition of angiotensin converting enzyme activity in cultured endothelial cells by hypoxia.},
  author={S Alex Stalcup and Joel S Lipset and Jen Mei Woan and Ph. Leuenberger and Robert B. Mellins},
  journal={The Journal of clinical investigation},
  year={1979},
  volume={63 5},
  pages={966-76}
}
Endothelial cells in tissue culture degrade bradykinin and convert angiotensin I to angiotensin II. These are both functions of a single dipeptidyl hydrolase, angiotensin converting enzyme. Monolayer cultures were prepared from human, rabbit, pig, and calf vessels. Angiotensin converting enzyme activity was assessed by adding either bradykinin or angiotensin I to the cells in culture flasks, and measuring residual peptide over time by radioimmunoassay. Peptide degradation was inhibited by the… CONTINUE READING

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