Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system.

@article{Garcia2010InhibitionOA,
  title={Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system.},
  author={Patric Garcia and Susanne P Schwenzer and Jan Erik Slotta and Claudia Scheuer and Andrea E. Tami and J{\"o}rg Holstein and T. Scheuer Histing and Markus Burkhardt and Tim Pohlemann and Michael Dieter Menger},
  journal={British journal of pharmacology},
  year={2010},
  volume={159 8},
  pages={1672-80}
}
BACKGROUND AND PURPOSE The renin-angiotensin system (RAS) regulates blood pressure and electrolyte homeostasis. In addition, 'local' tissue-specific RAS have been identified, regulating regeneration, cell growth, apoptosis, inflammation and angiogenesis. Although components of the RAS are expressed in osteoblasts and osteoclasts, a local RAS in bone has not yet been described and there is no information on whether the RAS is involved in fracture healing. Therefore, we studied the expression and… CONTINUE READING

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