Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma.

  title={Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma.},
  author={Erik Wassberg and Fredrik Hedborg and Erik Sk{\"o}ldenberg and Mats Stridsberg and Rolf H B Christofferson},
  journal={The American journal of pathology},
  volume={154 2},
Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell… CONTINUE READING


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