Inhibition of angiogenesis and invasion in malignant gliomas.

  title={Inhibition of angiogenesis and invasion in malignant gliomas.},
  author={Andrew Chi and Andrew David Norden and Patrick Yung Chih Wen},
  journal={Expert review of anticancer therapy},
  volume={7 11},
Malignant gliomas confer a dismal prognosis. As the molecular events that underlie tumor angiogenesis are elucidated, angiogenesis inhibition is emerging as a promising therapy for recurrent and newly diagnosed tumors. Data from animal studies suggest that angiogenesis inhibition may promote an invasive phenotype in tumor cells. This may represent an important mechanism of resistance to antiangiogenic therapies. Recent studies have begun to clarify the mechanisms by which glioma cells detach… CONTINUE READING