Inhibition of androgen binding in human foreskin fibroblasts by antiandrogens.

@article{Brown1981InhibitionOA,
  title={Inhibition of androgen binding in human foreskin fibroblasts by antiandrogens.},
  author={Terry R. Brown and Stephen W Rothwell and Ch Sultan and Claude J. Migeon},
  journal={Steroids},
  year={1981},
  volume={37 6},
  pages={635-48}
}
Antiandrogen effects on androgen receptor binding and androgen metabolism were studied in cultured human newborn foreskin fibroblasts. Three different antiandrogens were tested in this system: (a) cyproterone acetate (CA); (b) RU23908; and (c) R2956. CA and R2956 were equipotent inhibitors of androgen binding to its intracellular receptor. The magnitude of this action was nearly twice as great against the endogenous androgen ligands, dihydrotestosterone (DHT) or testosterone (T), than with the… CONTINUE READING