Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids.

@article{Watanabe1996InhibitionOA,
  title={Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids.},
  author={Kazuyuki Watanabe and Yoshiyuki Kayano and Tamihide Matsunaga and Ikuo Yamamoto and Hidetoshi Yoshimura},
  journal={Biological & pharmaceutical bulletin},
  year={1996},
  volume={19 8},
  pages={
          1109-11
        }
}
  • Kazuyuki Watanabe, Yoshiyuki Kayano, +2 authors Hidetoshi Yoshimura
  • Published in
    Biological & pharmaceutical…
    1996
  • Chemistry, Medicine
  • Mouse brain microsomes contain an amidase that catalyzes the hydrolysis of N-arachidonylethanolamide to arachidonic acid and ethanolamine. The enzymatic activity is dependent on the protein concentration of the microsomes and observed over a wide range of pH, 7.4 to 9.5. Kinetic analysis indicated that K(m) (microM) and Vmax (nmol/min/mg protein) were 17.7 +/- 4.1 and 1.81 +/- 0.32, respectively. Cannabidiol (CBD), cannabinol (CBN) and delta 9-tetrahydrocannabinol (delta 9-THC) significantly… CONTINUE READING

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