Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.

@article{Cohen2006InhibitionOA,
  title={Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.},
  author={Tomer Cohen and Anat Frydman-Marom and Meirav Rechter and Ehud Gazit},
  journal={Biochemistry},
  year={2006},
  volume={45 15},
  pages={
          4727-35
        }
}
  • Tomer Cohen, Anat Frydman-Marom, +1 author Ehud Gazit
  • Published in Biochemistry 2006
  • Chemistry, Medicine
  • Gaining insight into the mechanism of amyloid fibril formation, the hallmark of multiple degenerative syndromes of unrelated origin, and exploring novel directions of inhibition are crucial for preventing disease development. Specific interactions between aromatic moieties were suggested to have a key role in the recognition and self-assembly processes leading to the formation of amyloid fibrils by several amyloidogenic polypeptides, including the beta-amyloid polypeptide associated with… CONTINUE READING

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