Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans.

@article{Kim2000InhibitionOA,
  title={Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans.},
  author={Kwang Sik Kim and Sanjeev Kumar and William Harold Michael Garth Simmons and Nancy J. Brown},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 1},
  pages={295-8}
}
Bradykinin is a nonapeptide that contributes to the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitors. During ACE inhibition, an increased proportion of bradykinin is degraded through non-ACE pathways. Studies in animals suggest that aminopeptidase P (EC 3.4.11.9) may contribute to the metabolism of bradykinin. The purpose of the present study was to determine the contribution of aminopeptidase P to the degradation of bradykinin in humans in the presence and absence of… CONTINUE READING

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Aminopeptidases in Biology and Disease

Proteases in Biology and Disease • 2004

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