Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites.

@article{Carpn1995InhibitionOA,
  title={Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites.},
  author={Christian Carp{\'e}n{\'e} and Philippe Collon and Anne Remaury and Alex A. Cordi and Andrew Hudson and David Nutt and Max Lafontan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={681-8}
}
Nonadrenergic imidazoline binding sites (imidazoline I2 sites) have been described to be colocated with monoamine oxidase (MAO) in the mitochondrial fraction of various cell types. In the present work, the authors considered whether this colocation could be associated with a functional interplay. In rat liver membranes, [3H]-idazoxan binding to I2 receptors was competed for by naphazoline and idazoxan, which also shared a high affinity for alpha-2 adrenoceptors (alpha-2 ARs). The chemicals 2-n… CONTINUE READING