Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases.

@article{Nemeth2003InhibitionOA,
  title={Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases.},
  author={Jeffrey A. Nemeth and Michael L. Cher and Zhao Pin Zhou and Charles E. Mullins and Sunita D. Bhagat and Mohit Trikha},
  journal={Clinical & experimental metastasis},
  year={2003},
  volume={20 5},
  pages={
          413-20
        }
}
The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth and angiogenesis, and is known to be critical to osteoclast formation and activity. This study was designed to examine the role of alpha(v)beta3 expressed by cells native to the… CONTINUE READING

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