Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.

@article{Zhang1999InhibitionOA,
  title={Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.},
  author={D H Zhang and Liqun Yang and Lauren Cohn and Lisa Parkyn and Robert Homer and Prabir Ray and Anuradha Ray},
  journal={Immunity},
  year={1999},
  volume={11 4},
  pages={473-82}
}
The cytokines IL-4, IL-5, and IL-13, secreted by Th2 cells, have distinct functions in the pathogenesis of asthma. We have previously shown that the transcription factor GATA-3 is expressed in Th2 but not Th1 cells. However, it was unclear whether GATA-3 controls the expression of all Th2 cytokines. Expression of a dominant-negative mutant of GATA-3 in mice in a T cell-specific fashion led to a reduction in the levels of all the Th2 cytokines IL-4, IL-5, and IL-13. Airway eosinophilia, mucus… CONTINUE READING

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