Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia.

@article{Schwartz1995InhibitionOA,
  title={Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia.},
  author={Edward L. Schwartz and Susan Hallam and Robert E. Gallagher and Peter H. Wiernik},
  journal={Biochemical pharmacology},
  year={1995},
  volume={50 7},
  pages={923-8}
}
All-trans-retinoic acid induces acute promyelocytic leukemia cell differentiation in vitro, and it produces greater than 90% complete remissions in patients with acute promyelocytic leukemia. Despite the high response rate, the majority of patients relapse with continued trans-retinoic acid therapy, and disease progression has been observed to be accompanied by an increase in the metabolism of trans-retinoic acid in the patients. In this study, the pharmacokinetic disposition of trans-retinoic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Molecular aspects of azoles-induced teratogenesis.

Expert opinion on drug metabolism & toxicology • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…