Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists.

@article{Doghman2009InhibitionOA,
  title={Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists.},
  author={Mabrouka Doghman and Julie Cazareth and Dominique Douguet and Franck Madoux and Peter S. Hodder and Enzo Lalli},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 6},
  pages={2178-83}
}
CONTEXT Transcription factor steroidogenic factor-1 (SF-1) plays a pivotal role in the control of adrenocortical cell steroidogenesis and proliferation. SF-1 amplification and overexpression are found in most cases of childhood adrenocortical tumors (ACTs). OBJECTIVE Our objective was to investigate the effect of SF-1 inverse agonists of the alkyloxyphenol and isoquinolinone classes on the proliferation of human adrenocortical cell lines expressing SF-1 (H295R), in conditions of basal and… CONTINUE READING
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Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes

  • AL Del Tredici, CB Andersen, +6 authors F Piu
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