Inhibition of adrenaline-induced fibrinolysis by alpha-adrenergic blocking agents in the rat.

@article{Sasaki1974InhibitionOA,
  title={Inhibition of adrenaline-induced fibrinolysis by alpha-adrenergic blocking agents in the rat.},
  author={Y. Sasaki and S. Takeyama},
  journal={Japanese journal of pharmacology},
  year={1974},
  volume={24 5},
  pages={
          737-45
        }
}
  • Y. Sasaki, S. Takeyama
  • Published 1974
  • Medicine, Chemistry
  • Japanese journal of pharmacology
  • Abstract The fibrinolysis induced by intraperitoneal injection of adrenaline in the rat was inhibited by prior intraperitoneal injection of very low doses of α-adrenergic blocking agents. For example, 5 μg/kg of phenoxybenzamine or 10 μg/kg of phentolamine was sufficient to prevent almost completely the fibrinolysis induced by 1 mg/kg of adrenaline. These α-blockers also inhibited the fibrinolysis induced by serotonin and bisobrin, but a much higher dosage was required. Phenoxybenzamine did not… CONTINUE READING
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