Inhibition of adenosine triphosphatases by gold.

@article{Nechay1980InhibitionOA,
  title={Inhibition of adenosine triphosphatases by gold.},
  author={B. R. Nechay},
  journal={Arthritis and rheumatism},
  year={1980},
  volume={23 4},
  pages={
          464-70
        }
}
  • B. R. Nechay
  • Published 1980
  • Chemistry, Medicine
  • Arthritis and rheumatism
Inhibition of adenosine triphosphatase (ATPase) by chlorauric acid (Au3+) and gold sodium thiomalate (Au+) was studied in dog brain and kidney and in human kidney enzyme preparations. Au3+ indiscriminately affected ouabain-sensitive (Na+ + K+-dependent) ATPase and ouabain-insensitive (Mg2+-dependent) ATPase with concentrations for 50% inhibition (I50) approximately 10(-6) M. The I50 of Au3+ for Na+ + K+ ATPase was several-fold higher in homogenates than in microsomal fractions. The enzyme was… Expand
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