Inhibition of adenosine kinase induces expression of VEGF mRNA and protein in myocardial myoblasts.

@article{Gu2000InhibitionOA,
  title={Inhibition of adenosine kinase induces expression of VEGF mRNA and protein in myocardial myoblasts.},
  author={J. Gu and B. Ito and A. Sartin and N. Frascogna and M. Moore and T. Adair},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 5},
  pages={
          H2116-23
        }
}
  • J. Gu, B. Ito, +3 authors T. Adair
  • Published 2000
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • We tested whether increased endogenous adenosine produced by the adenosine kinase inhibitor GP-515 (Metabasis Therapeutics) can induce vascular endothelial growth factor (VEGF) expression in cultured rat myocardial myoblasts (RMMs). RMMs were cultured for 18 h in the absence (control) and presence of GP-515, adenosine (Ado), adenosine deaminase (ADA), or GP-515 + ADA. GP-515 (0.2-200 microM) caused a dose-related increase in VEGF protein expression (1.99-2.84 ng/mg total cell protein); control… CONTINUE READING
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