Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.

  title={Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.},
  author={Luca Antonioli and Matteo Fornai and Rocchina Colucci and Narcisa Ghisu and Federico da Settimo and Gianfranco Natale and Olga Kastsiuchenka and Emiliano Duranti and Agostino Virdis and Cristina Vassalle and Concettina La Motta and Laura Mugnaini and Maria Cristina Breschi and C Blandizzi and Mario Del Taca},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={322 2},
Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions. Drugs able to prevent adenosine catabolism could represent an innovative strategy to treat inflammatory bowel disorders. In this study, the effects of 4-amino-2-(2-hydroxy-1-decyl)pyrazole[3,4-d]pyrimidine (APP; novel adenosine deaminase inhibitor), erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride (EHNA; standard adenosine deaminase inhibitor), and dexamethasone… CONTINUE READING


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