Inhibition of acute myelogenous leukemia blast proliferation by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors.

@article{Estrov1992InhibitionOA,
  title={Inhibition of acute myelogenous leukemia blast proliferation by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors.},
  author={Zeev Estrov and Razelle Kurzrock and E H Estey and Meir Wetzler and Allessandra Ferrajoli and David Harris and Marilyn Blake and Jordan U. Gutterman and Moshe Talpaz},
  journal={Blood},
  year={1992},
  volume={79 8},
  pages={1938-45}
}
Interleukin-1 (IL-1) has recently been reported to play an important role in acute myelogenous leukemia (AML) blast proliferation. We therefore investigated the effect of soluble IL-1 receptors (sIL-1R) and IL-1 receptor antagonist (IL-1RA) on the growth of AML bone marrow blast progenitors from 25 patients. In the AML blast colony culture assay, sIL-1R and IL-1RA inhibited blast colony-forming cell replication in a dose-dependent fashion, at concentrations ranging from 10 to 500 ng/mL (sIL-1R… CONTINUE READING

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Acute myelogenous leukemia

MA Lichtman, ES Henderson
1990

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