Inhibition of active NaCl reabsorption in the thick ascending limb of the loop of Henle by torasemide.

@article{Greger1988InhibitionOA,
  title={Inhibition of active NaCl reabsorption in the thick ascending limb of the loop of Henle by torasemide.},
  author={Rainer Greger},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 1A},
  pages={151-2}
}
The new diuretic torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) was tested in isolated in vitro perfused cortical thick ascending limbs of Henle loops of rabbit kidney. The equivalent short circuit current (Isc) corresponding in this nephron segment to the rate of secondarily active Cl-reabsorption was measured continuously. Torasemide led to a rapid and reversible inhibition of Isc when added to the luminal perfusate. The IC50 for this effect was 3 x 10(-7) mol… CONTINUE READING