Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants

@article{Lian2004InhibitionOA,
  title={Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants},
  author={Xiao-Yuan Lian and Janet L. Stringer},
  journal={Epilepsy Research},
  year={2004},
  volume={60},
  pages={41-52}
}
Although there is evidence that astrocytes support neuronal function, the contribution of astrocytes to seizure onset and termination is not known. To determine whether there are changes in seizure susceptibility or neuronal damage when the ability of astrocytes to generate ATP is reduced, 0.5 nmol of fluorocitrate (FC) was injected into the right ventricle. Injection of FC alone did not produce electrographic or behavioral seizures and did not stress or injure neurons or astrocytes, as… CONTINUE READING

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