Inhibition of acetylcholinesterase by two arylderivatives: 3a-Acetoxy-5H-pyrrolo (1,2-a) (3, 1)benzoxazin- 1,5-(3aH)-dione and cis-N-p-Acetoxy-phenylisomaleimide.

@article{CorreaBasurto2006InhibitionOA,
  title={Inhibition of acetylcholinesterase by two arylderivatives: 3a-Acetoxy-5H-pyrrolo (1,2-a) (3, 1)benzoxazin- 1,5-(3aH)-dione and cis-N-p-Acetoxy-phenylisomaleimide.},
  author={Jos{\'e} Correa-Basurto and J. Espinosa-Raya and Mario Gonz{\'a}lez-May and L Michel Espinoza-Fonseca and Iv{\'a}n V{\'a}zquez-Alc{\'a}ntara and Jos{\'e} Guadalupe Trujillo-Ferrara},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2006},
  volume={21 2},
  pages={133-8}
}
Two arylderivatives, 3a-Acetoxy-5H-pyrrolo(1,2-a) (3,1)benzoxazin-1,5-(3aH)-dione 3 and cis-N-p-Acetoxy-phenylisomaleimide 4, were synthesized from anthranilic acid and para-aminophenol, respectively. The inhibitory effects of these compounds on acetylcholinesterase (AChE) activity were evaluated in vitro as well as by docking simulations. Both compounds showed inhibition of AChE activity (Ki = 4.72 +/- 2.3 microM for 3 and 3.6 +/- 1.8 microM for 4) in in vitro studies. Moreover, they behaved… CONTINUE READING
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