Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids.

@article{Miyazawa2005InhibitionOA,
  title={Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids.},
  author={Mitsuo Miyazawa and Chikako Yamafuji},
  journal={Journal of agricultural and food chemistry},
  year={2005},
  volume={53 5},
  pages={1765-8}
}
Inhibition of acetylcholinesterase (AChE) activity by 17 kinds of bicyclic monoterpenoids was investigated. Bicyclic monoterpenoids are contained in many kinds of essential oils. Inhibition of AChE was measured according to the colorimetric method. 3.1.1 and 4.1.0 bicyclic hydrocarbons with allylic methyl group showed strong inhibition. (+)- and (-)-alpha-pinene and (+)-3-carene were potent inhibitors of AChE. 3.1.1 and 2.2.1 bicyclic alcohols and ketones showed weak inhibition. 3.1.1 and 4.1.0… CONTINUE READING

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