Inhibition of acetylcholinesterase activity as effect criterion in acute tests with juvenile Daphnia magna.

@article{Guilhermino1996InhibitionOA,
  title={Inhibition of acetylcholinesterase activity as effect criterion in acute tests with juvenile Daphnia magna.},
  author={L{\'u}cia Guilhermino and Maria Celeste Lopes and Ars{\'e}lio P. Carvalho and Amadeu M V M Soares},
  journal={Chemosphere},
  year={1996},
  volume={32 4},
  pages={
          727-38
        }
}
In this work we investigated the possibility of using the enzyme acetylcholinesterase (AChE) activity in Daphnia magna homogenates, both in vivo and in vitro conditions, as a specific method for rapid toxicity evaluations. The results from in vivo and in vitro AChE inhibition tests were compared with 48 hours EC50 values obtained in conventional acute bioassays. EC50 values from in vivo AChE inhibition tests were: 2.4 micrograms/l for parathion, 0.2 microgram/l for paraoxon; DCA and cadmium at… CONTINUE READING

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