Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice

@article{Glund2012InhibitionOA,
  title={Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice},
  author={Stephan Glund and Corinna Schoelch and Leo Thomas and Heiko G. Niessen and Dankwart Stiller and Gerald J. Roth and Heike Neubauer},
  journal={Diabetologia},
  year={2012},
  volume={55},
  pages={2044-2053}
}
Excessive ectopic lipid deposition contributes to impaired insulin action in peripheral tissues and is considered an important link between obesity and type 2 diabetes mellitus. Acetyl-CoA carboxylase 2 (ACC2) is a key regulatory enzyme controlling skeletal muscle mitochondrial fatty acid oxidation; inhibition of ACC2 results in enhanced oxidation of lipids. Several mouse models lacking functional ACC2 have been reported in the literature. However, the phenotypes of the different models are… CONTINUE READING