Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria.

@article{Bistu2009InhibitionOA,
  title={Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria.},
  author={Alfonso J. C. Soler Bistu{\'e} and Fernando Ariel Martin and Nicol{\'a}s Vozza and Hongphuc P Ha and Jonathan C Joaqu{\'i}n and {\'A}ngeles Zorreguieta and Marcelo E. Tolmasky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={13230-5}
}
Inhibition of bacterial gene expression by RNase P-directed cleavage is a promising strategy for the development of antibiotics and pharmacological agents that prevent expression of antibiotic resistance. The rise in multiresistant bacteria harboring AAC(6')-Ib has seriously limited the effectiveness of amikacin and other aminoglycosides. We have recently shown that recombinant plasmids coding for external guide sequences (EGS), short antisense oligoribonucleotides (ORN) that elicit RNase P… CONTINUE READING

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