• Biology, Medicine
  • Published in Journal of immunology 1999

Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide.

@article{Mizuno1999InhibitionOA,
  title={Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide.},
  author={Masashi Mizuno and Kazuhiro Nishikawa and Naoki Okada and Seiichi Matsuo and Kouichi Ito and Hiroshi Okada},
  journal={Journal of immunology},
  year={1999},
  volume={162 9},
  pages={
          5477-82
        }
}
Rats pretreated with traces of LPS developed acute fatal shock syndrome after i.v. administration of a mAb that inhibits the function of a membrane complement regulatory molecule. Such a shock was not observed after the administration of large amounts of LPS instead of the mAb following LPS pretreatment. The lethal response did not occur in rats depleted of either leukocytes or complement, and a C5a receptor antagonist was found to inhibit the reaction. Furthermore, LPS-treated rats did not… CONTINUE READING

Citations

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