Inhibition of a DNA-helicase by peptide nucleic acids.

@article{Bastide1999InhibitionOA,
  title={Inhibition of a DNA-helicase by peptide nucleic acids.},
  author={Lionel Bastide and Paul E. Boehmer and Giuseppe Villani and Bernard Lebleu},
  journal={Nucleic acids research},
  year={1999},
  volume={27 2},
  pages={
          551-4
        }
}
Bis-peptide nucleic acid (bis-PNA) binding results in D-loop formation by strand displacement at complementary homopurine stretches in DNA duplexes. Transcription and replication in intact cells is mediated by multienzymatic complexes involving several proteins other than polymerases. The behaviour of the highly stable clamp structure formed by bis-PNAs has thus far been studied with respect to their capacity to arrest RNA polymerases. Little attention has been given to their recognition and… CONTINUE READING

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