Inhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo

@inproceedings{Li2016InhibitionOY,
  title={Inhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo},
  author={Hui Li and Zhenglan Huang and Miao Gao and Ningshu Huang and Zhenhong Luo and Huawei Shen and Xin Wang and Teng Wang and Jing Hu and Wenli Feng},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2016}
}
BACKGROUND Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS The expression of YAP in CML cells was determined by western blotting. Next, the effects of YAP knockdown and YAP inhibitor on CML cells were evaluated by MTT assay, flow cytometry (FCM) and Wright's staining. Moreover, K562… CONTINUE READING

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